The Relationship Between Bone Health and Nutrition in Children with Cerebral Palsy
DOI:
https://doi.org/10.5281/zenodo.15714096Keywords:
Bone Health , Cerebral Palsy , NutritionAbstract
Cerebral palsy (CP) is a non-progressive motor disorder resulting from damage to the developing brain, primarily affecting motor functions. It occurs in approximately 2–3 out of every 1,000 live births. Prenatal, perinatal, and postnatal factors can contribute to its development. Children with CP often experience feeding difficulties due to conditions such as dysphagia, gastroesophageal reflux, and nausea. These issues can lead to inadequate intake of energy, protein, vitamins, and minerals, which in turn negatively affect bone health by increasing the risk of conditions like osteoporosis and fractures. In non-ambulatory children with CP, bones are not subjected to sufficient mechanical loading, which leads to decreased bone mineral density (BMD). Studies have shown that children with quadriplegic CP have significantly decrease BMD, and a positive correlation exists between low BMD and vitamin D deficiency. Nutrition plays a key role in managing CP and supporting optimal bone development. Particular attention should be given to vitamin D and calcium intake, which are essential for bone health. However, nutritional care is often overlooked in this population. Therefore, individualized nutritional therapy should be planned and monitored by both physicians and dietitians to prevent deficiencies and support overall health in children with CP.
References
Asalu, A. M., Taylor, G., Campbell, H., Lelea, L. L., & Kirby, R. S. (2019). Cerebral palsy: diagnosis, epidemiology, genetics, and clinical update. Advances in Pediatrics, 66, 189–208. [CrossRef] [PubMed]
Graham, D., Paget, S. P., & Wimalasundera, N. (2019). Current thinking in the health care management of children with cerebral palsy. Medical Journal of Australia, 210(3), 129–135. [CrossRef] [PubMed]
Paul, S., Nahar, A., Bhagawati, M., & Kunwar, A. J. (2022). A review on recent advances of cerebral palsy. Oxidative Medicine and Cellular Longevity, 2022:2622310. [CrossRef] [PubMed]
Korzeniewski, S. J., Slaughter, J., Lenski, M., Haak, P., & Paneth, N. (2018). The complex aetiology of cerebral palsy. Nature Reviews Neurology, 14, 528–543. [CrossRef] [PubMed]
Sadowska, M., Sarecka-Hujar, B., & Kopyta, I. (2020). Cerebral palsy: current opinions on definition, epidemiology, risk factors, classification and treatment options. Neuropsychiatric Disease and Treatment, 16:1505–1518. [CrossRef] [PubMed]
Carman, K. B., Aydın, K., Aydın, B. K., Cansu, A., Direk, M. Ç., & Durmuş, S. (2021). Evaluation of micronutrient levels in children with cerebral palsy. Pediatrics International, 64(1), e15005. [CrossRef] [PubMed]
Cieri, M. E., Brunner, M. M. R., Condananzi, A.L., Escobar, J., & Cuestas, E. (2023). Nutritional status and dietary intake of children and adolescents with cerebral palsy. Clinical Nutrition ESPEN, 57, 391–398. [CrossRef] [PubMed]
Verschuren, O., Smorenburg, A., Luiking, Y., Bell, K., Barber, L., & Peterson, M. (2018). Determinants of muscle preservation in individuals with cerebral palsy across the lifespan: a narrative review of the literature. Journal of Cachexia, Sarcopenia and Muscle, 9(3), 453–464. [CrossRef] [PubMed]
Oftedal, S., Cormack, S., Stevenson, R., Benfer, K., Boyd, R., & Bell, K. (2024). The evolution of nutrition management in children with severe neurological impairment with a focus on cerebral palsy. Journal of Human Nutrition and Dietetics, 38(1):e13277. [CrossRef] [PubMed]
Dimitrova, R. P., Toneva, A., Georgieva, M., Konstantinova, D., & Petrova, S. (2018). Nutritional status, macro- and micronutrient deficiency in children with neurodevelopmental disorders. Scripta Scientifica Salutis Publicae, 4:7–14. [CrossRef]
Connor, G., van der Linde, M., & Capriles, Z. H. (2024). The impact of low-energy, partially hydrolysed enteral formula on gastrointestinal symptoms and weight in children with neurological impairment: a multicentre retrospective study. Journal of Human Nutrition and Dietetics, 37(1), e13305. [CrossRef] [PubMed]
Alenazi, K. A. (2022). Vitamin D deficiency in children with cerebral palsy: A narrative review of epidemiology, contributing factors, clinical consequences and interventions. Saudi Journal of Biological Sciences, 29(4), 2007–2013. [CrossRef] [PubMed]
Akpinar, P. (2018). Vitamin D status of children with cerebral palsy: Should vitamin D levels be checked in children with cerebral palsy? North Clin Istanbul, 5(4), 341–347. [CrossRef] [PubMed]
Song, L. (2017). Chapter One Calcium and Bone Metabolism Indices. Advances in Clinical Chemistry, 82, 1–46. [CrossRef] [PubMed]
Jesus, A., & Stevenson, R. (2020). Optimizing nutrition and bone health in children with cerebral palsy. Physical Medicine and Rehabilitation Clinics of North America, 31(1), 25–37. [CrossRef] [PubMed]
Zaragova, C. A., Garibay, E. D., Contreras, A. A., Haro, A. L., Velarde, E. R., Rosas, A. R., & Olea, I. V. (2018). Bone mineral density and nutritional status in children with quadriplegic cerebral palsy. Archives of Osteoporosis, 13(1), 17. [CrossRef] [PubMed]
Garibay, E. M. V., Zaragova, C. A., Contreras, A. A., Haro, L. A., Velorde, E. R., Rosas, A. R., & Olea, I. V. (2018). Bone mineral density and biochemical and hormonal indicators in children with quadriplegic cerebral palsy. Nutrición Hospitalaria, 36(3), 517–525. [CrossRef] [PubMed]
Barbier, V., Goeb, V., Gouron, R., Fritot, S., Mentaverri, R., & Klein, C. (2023). Bone health in children with severe cerebral palsy. Frontiers in Pediatrics, 11:1158940. [CrossRef] [PubMed]
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